Green Chemistry Approach gives World record in cascade synthesis to produce Centrocountins that inhibit cell division in Cancer
Most of the organic syntheses are very complex and follow certain sequence of number of reactions and intermediates in reactions to get the final product. Moreover they are very time consuming reactions. As contrary to these reactions cascades reactions were directly give the end product in fast way and minimum time. This is because this type of reactions are started the first step to reach the end product by way of a series of successive intermediate products and steps. This entire cascade reaction takes place in a single reaction vessel so this process saves time, energy, costs.
Scientist of Max Plank Instituteof Molecular Physiology in Dortmund succeeds in developing the longest reaction that is cascade in single vessel. They developed a biologically active substance called Centrocountins. If we go to produce this substance by the traditional way we required a week to get the final product as Centrocountins. By the cascade synthesis reaction, Centrocountins which inhibit cancer cell to multiply are produce in 12individual steps and required 10 to 30 minutes for whole reaction. The reaction commence with simple tryptamine derivatives and include nine different individual reactions over twelve steps, which involve the use of two different catalytic mechanisms.This reaction holds current World record in cascade synthesis known to cascade the longest reaction. The research work of these scientist were published in the Nature Journal on December 2011
Cells treated with Centrocountins divide in three or more daughter cells which were not feasible. Centrosomes of cell make certain arrangement for correct separation of the chromosomes between the two daughter cells during cell division. So, Results of treatment with Centrocountins shows a dividing cell has multiple spindles poles instead of two. Moreover as an end result the cell can no longer correctly count its centrosomes .Hence scientist give the name of substance "Centrocountin". In the Meta phase chromosomes were unable to adjust themselves correctly .Hence cell division cycle comes to an end .By this way the in cancer, tumors cells are commit cellular suicide and did not multiply.
This new kind of substance called Centrocountins produced by the cascade reaction synthesis offer a proficient opening point for the development of new tumors therapies and anti tumors drugs.
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